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| Catalog No. | Product Name | Size | List Price (US$) | Quantity |
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Conditions of optimal VDR Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Introduction
Vitamin D receptors (VDRs) belong to the NR1I family, which also includes pregnane X (PXR) and constitutive androstane (CAR) receptors which form heterodimers with members of the retinoid X receptor family. VDR is expressed in the intestine, thyroid and kidney and has an imperative role in calcium homeostasis. VDRs inhibit expression of 1alpha-hydroxylase (the proximal activator of 1,25(OH)2D3 and induce expression of the 1,25(OH)2D3 inactivating enzyme CYP24. Additionally, VDR has recently been recognized as an additional bile acid receptor alongside FXR and may function to protect gut against the toxic and carcinogenic effects of these endobiotics. Hereditary mutations in the VDR gene leads to rickets, which is typified by muscle weakness, growth retardation, bone deformity and secondary hyperparathyroidism. The human gene encoding the VDR is localized to chromosome 12q12-q14.
BP002096-PRO-205: Recombinant Human Vitamin D Receptor (VDR) Protein
Source: E. coli-derived.
Recombinant Human Vitamin D Receptor (VDR) Protein is a full length protein consisting of 427 amino acids having a molecular weight of 48.3 kDa and fused with 5.5 kDa amino-terminal His-Flag tag. Recombinant Human Vitamin D Receptor (VDR) Protein is purified by proprietary chromatographic techniques.
Purity: > 70% as determined by SDS-PAGE.
Formulation: VDR protein is supplied in 50 mM Tris, 150 mM NaCl and 10% Glycerol, pH 7.5.
Shipping: The product is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
VDR Antibody:
VDR Polyclonal Antibody
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