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Background Information:
Valsartan is a potent, selective and orally active AT1 receptor antagonist (Ki = 2.38 nM), with over 30,000-fold selectivity over AT2 receptors. It is an investigational antihypertensive drug being studied for use in combination with AHU-377 (molar ratio: 1:1) (Our Prod No. CT-AHU377). The combination drug, known as LCZ696, is in clinical trials for the treatment of heart failure.
Reference:
1. L. Criscione, et al, Pharmacological profile of Valsartan: a potent, orally active, nonpeptide antagonist of the angiotensin II AT1-receptor subtype, Br J Pharmacol, 1993, Oct; 110(2):761-71.
2. S. Hanafy, et al, Effects of angiotensin II blockade on inflammation-induced alterations of pharmacokinetics and pharmacodynamics of calcium channel blockers, Br J Pharmacol, 2008 Jan; 153(1):90-9.
3. A. A. Voors, et al., The potential role of valsartan + AHU377 ( LCZ696 ) in the treatment of heart failure. Expert Opin Investig Drugs. 2013 Aug. 22(8):1041-7.
APIM050349: VALSARTAN
CAS No.: 137862-53-4.
Molecular Formula: C24H29N5O3.
Molecular Weight: 435.5.
Purity: >99% (HPLC at 214 and 254 nm).
QC: HPLC-MS, 1HNMR.
Solubility: Soluble in DMSO.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.
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