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Conditions of optimal UROS Enzyme performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
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Introduction
Uroporphyrinogen-III synthase, also known as Hydroxymethylbilane hydrolyase, Uroporphyrinogen-III cosynthase and UROS, is an enzyme which belongs to the uroporphyrinogen-III synthase family. UROS is ubiquitous and involved in Porphyrin metabolism. Porphyrins act as cofactors for a multitude of enzymes that perform a variety of processes within the cell such as methionine synthesis (vitamin B12) or oxygen transport (heme). UROS can catalyze cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, the branch point for the various sub-pathways leading to the wide diversity of porphyrins. Defects in this protein are the cause of congenital erythropoietic porphyria (CEP).
BP001381-ENZ-140: Recombinant Human Uroporphyrinogen-III synthase (UROS) Enzyme
Source: E. coli-derived.
A single, non-glycosylated polypeptide chain containing 285 amino acids (1-265 a.a.) and having a molecular mass of 30.7 kDa. UROS is fused to a 20 amino acid His-tag at N-terminus.
Purity: > 95% by SDS-PAGE.
Formulation: UROS protein solution (1 ug/ml) containing 20 mM Tris-HCl buffer (pH8.0), 10% glycerol and 0.1 M NaCl.
Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
Other UROS Enzymes:
Recombinant Human UROS Enzyme
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