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Home > Proteins & Peptides > A-Z Proteins  > UMOD Protein

UMOD Protein

Uromodulin, Tamm-Horsfall urinary glycoprotein, THP, FJHN, HNFJ, THGP, MCKD2, ADMCKD2

Catalog No. Product Name Size List Price (US$) Quantity
BP000733-ENZ-334 Canine Uromodulin 10 ug 160.00
BP000733-ENZ-334 Canine Uromodulin 1 mg 5200.00
Description

Introduction
Uromodulin is the most abundant protein in normal urine. Its secretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. Uromodulin plays a role as a constitutive inhibitor of calcium crystallization in renal fluids. Secretion of uromodulin in urine provides protection against urinary tract infections caused by uropathogenic bacteria. Defects in Uromodulin expression are associated with the autosomal dominant renal disorders medullary cystic kidney disease-2 (MCKD2) and familial juvenile hyperuricemic nephropathy (FJHN). These disorders are characterized by juvenile onset of hyperuricemia, gout, and progressive renal failure. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. UMOD is involved in regulating the circulating activity of cytokines as it binds to il-1, il-2 and tnf with high affinity.

BP000733-ENZ-334: Canine Uromodulin

Source: Canine Urine-derived.
An 85-kDa glycoprotein which is produced in the thick ascending limb of Henle? loop and early distal convoluted tubules of the nephron.
Formulation: The UMOD protein was lyophilized from 0.4 ? filtered solution at a concentration of 0.1 ug/ml containing deionized water.
Reconstitution: Add deionized water to prepare a working stock solution of approximately 0.5 mg/mL and let the lyophilized pellet dissolve completely. Product is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.

Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.

Other UMOD Proteins:
Human Uromodulin

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