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Conditions of optimal UBE2H Enzyme performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
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Introduction
Ubiquitin-conjugating enzyme E2 H, also known as UBE2H and UbcH2, belongs to the E2 ubiquitin-conjugating enzyme family. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. It has been shown to conjugate ubiquitin to histone H2A in an E3 dependent manner in vitro. UBE2H is the human homolog to the yeast DNA repair gene RAD6, which is induced by DNA damaging reagents. UBE2H has been associated with cancer-induced cachexia and with the regulation of sepsis-induced muscle proteolysis.
BP001057-ENZ-603: Recombinant Human Ubiquitin-conjugating enzyme E2 H (UBE2H) Enzyme
Source: E. coli-derived.
A single, non-glycosylated polypeptide chain containing 206 amino acids (1-183) and having a molecular mass of 23.1 kDa. UBE2H is fused to a 23 amino acid His-tag at N-terminus.
Purity: > 95% by SDS-PAGE.
Formulation: The UBE2H solution (1 ug/ml) contains 20 mM Tris-HCl buffer, pH8.0, 10% glycerol, 1 mM DTT and 50 mM NaCl.
Shipping: The product is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
Other UBE2H Enzymes:
Recombinant Human UBE2H Enzyme
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