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| Catalog No. | Product Name | Size | List Price (US$) | Quantity |
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Conditions of optimal TWF1 Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
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Introduction
Twinfilin (TWF1) is a ubiquitous actin-monomer-binding protein which is composed of two ADF-homology domains. Twinfilin forms a 1:1 complex with ADP-actin-monomers, prevents nucleotide exchange on actin monomers and blocks assembly of the monomer into filaments. TWF1 is composed of 2 ADF/cofilin-like (ADF-H) domains joined by a short linker region and followed by a C-terminal tail of approximately 20 residues. The 2 ADF-H domains are approximately 20% homologous to ADF/cofilin and to each other. TWF1 protein may be an actin monomer-binding protein, and its localization to cortical G-actin-rich structures might be regulated by the small GTPase RAC1.
BP002202-PRO-1003: Recombinant Human Twinfilin-1 (TWF1) Protein
Source: E. coli-derived.
Recombinant Human Twinfilin-1 (TWF1) Protein is a single, non-glycosylated polypeptide chain containing 277 amino acids (1-252 a.a.) and having a molecular mass of 31.5 kDa. Recombinant Human Twinfilin-1 (TWF1) Protein is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Purity: > 80% as determined by SDS-PAGE.
Formulation: TWF1 protein solution (0.25 mg/ml) containing 20 mM Tris-HCl buffer (pH 8.0), 40% glycerol, 0.15 M NaCl and 1 mM DTT.
Shipping: The product is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
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