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Conditions of optimal TRPC6 antibody performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
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Introduction
TRPC6 (Transient receptor potential cation channel, subfamily C, member 6), also known as TRP6, is a transient receptor potentialion channel.TRPC6 is a novel member of the TRPC family. The predicted 931-amino acid protein shares 93% identity with mouse Trpc6. Northern blot analysis revealed that TRPC6 is expressed primarily in placenta, lung, spleen, ovary, and small intestine. The TRPC6 gene is mapped on 11q22.1. TRPC6 is a nonselective cation channel that is activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Although TRPC3, the closest structural relative of TRPC6, is activated in the same manner, human TRPC1 and mouse Trpc4 and Trpc5 were unresponsive to DAG. Immunofluorescence studies showed that most TRPC6 expression is confined to podocytes. TRPC6 was also expressed in glomerular endothelial cells. Cardiac-specific overexpression of TRPC6 in transgenic mice resulted in heightened sensitivity to stress, a propensity for lethal cardiac growth and heart failure, and an increase in Nfat-dependent expression of beta-myosin heavy chain (MYH7), a marker for pathologic hypertrophy. Studies of Trpc6 -/- mice showed that Trpc6 has a role in regulation of smooth muscle tone in blood vessels and lung.
PA000528-PA1754: TRPC6 Polyclonal Antibody
Rabbit Polyclonal Antibody.
Applications: WB 0.1-0.5 ug/ml; IHC-P 0.5-1 ug/ml.
Reactivity: Human, Rat, Mouse.
Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human TRPC6, different from the related rat and mouse sequences by three amino acids.
Purification: Immunogen affinity purified.
Form of Antibody: Lyophilized.
Reconstitution: 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Isotype: Rabbit IgG.
Storage/Stability: Stable for 1 year at -20°C and 3 months at 4°C. For maximum recovery of the product, centrifuge the original vial after thawing and before removing the cap. Aliquot to avoid repeated freezing and thawing.
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