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Conditions of optimal TPM3 Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
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Introduction
Tropomyosin alpha-3 chain (TPM3) belongs to the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins which polymerize end-to-end along the major groove in most actin filaments. Tropomyosins give stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, tropomyosins regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Mutations in the TPM3 gene cause autosomal dominant nemaline myopathy, and oncogenes formed by chromosomal translocations involving this locus are linked with cancer.
BP002014-PRO-1020: Recombinant Human Tropomyosin-3 (TPM3) Protein
Source: E. coli-derived.
Recombinant Human Tropomyosin-3 (TPM3) Protein is a single, non-glycosylated polypeptide chain containing 272 amino acids (1-248 a.a.). Recombinant Human Tropomyosin-3 (TPM3) Protein is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Predicted molecular mass: 31.6 kDa.
Purity: > 90% by SDS-PAGE.
Formulation: TPM3 protein solution (0.5 mg/ml) containing 20 mM Tris-HCl buffer (pH 8.0), 1 mM DTT, 10% glycerol, 0.1 M NaCl.
Shipping: The product is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
TPM3 Protein:
Recombinant Human TPM3 Protein
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