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Conditions of optimal TIE2 Enzyme performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
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Or leave a message with a formal purchase
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Introduction
TIE-1 (tyrosine kinase with Ig and EGF homology domains 1) and TIE-2/Tek comprise a receptor tyrosine kinase (RTK) subfamily with unique structural characteristics: two immunoglobulin-like domains flanking three epidermal growth factor (EGF)-like domains and followed by three fibronectin type III-like repeats in the extracellular region and a split tyrosine kinase domain in the cytoplasmic region. These receptors are expressed primarily on endothelial and hematopoietic progenitor cells and play critical roles in angiogenesis, vasculogenesis and hematopoiesis. Human TIE-1 cDNA encodes a 1124 amino acid (aa) residue precursor protein with an 18 residue putative signal peptide, a 727 residue extracellular domain and a 354 residue cytoplasmic domain. Whereas two ligands have been described for TIE-2 [angiopoietin-1 (Ang1) and angiopoietin-2 (Ang2)], so far no ligand was found for TIE-1.
BP000919-PKA-248: Recombinant Human TIE2 Fc Chimera
Source: Insect Cells-derived.
A monomeric, glycosylated, polypeptide containing 730 amino acids and having a total molecular mass of 250 kDa.
Measured in a functional ELISA assay. When TIE-2/Fc is immobilized at 4 ?/mL (100 ?/well), it binds rh Angiopoietin-2 with a linear range of 2-100 ug/ml.
Purity > 90%, by RP-HPLC and SDS-PAGE.
Formulation: TIE-2 Fc Chimera was lyophilized from a concentrated (1 ug/ml) sterile solution containing 1x PBS.
Reconstitution: It is recommended to reconstitute the lyophilized TIE-2 Fc Chimera in sterile water not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.
Other TIE2 Enzymes:
Recombinant Mouse TIE2 Fc Chimera
TIE2 Antibodies:
TIE2 (Ab-1102) Polyclonal Antibody
TIE2 (Phospho-Tyr1108) Polyclonal Antibody
TIE2 (Phospho-Tyr1102) Polyclonal Antibody
TIE2 ELISA Kits:
Human TIE2 ELISA Kit
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