Name: TG Protein
Brand: Syd Labs
SKU: BP000501-PRO-443
Price: 160.00 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No.

Product Name

Size

List Price (US$)

Quantity

BP000501-PRO-443

Human TG Protein

100 ug

160.00

BP000501-PRO-443

Human TG Protein

1 mg

1200.00

Description

Introduction
Thyroglobulin (TG) represents one of the main autoantigenic targets in autoimmune thyroid disease of humans. TG is a large globular dimeric glycoprotein with a total molecular weight of 660 kDa, which occupies a key precursor role in the biosynthesis of the thyroid hormones. Approximately 75% of the total protein content of the thyroid follicle consists of TG. The thyroid gland uses the Thyroglobulin in order to produce the thyroid hormones thyroxine (T4) and triiodothyronine (T3). Thyroglobulin is produced by the thyroid epithelial cells (thyrocytes) which form spherical follicles. Thyroglobulin is subsequently secreted and stored in the follicular lumen.
Patients with Hashimoto's thyroiditis or Graves' disease, frequently develop antibodies against Thyroglobulin. Tg-specific antibodies help in the diagnosis of the above diseases, however they also may be present in apparently healthy euthyroid individuals. Blood Thyroglobulin levels can be used as a tumor marker for certain kinds of thyroid cancer, and the may also be elevated in cases of Graves' disease.

BP000501-PRO-443: Human Thyroglobulin (TG) Protein

Source: Native, Isolated from human thyroid glands-derived.
A glycosylated, polypeptide chain having a total molecular mass of 662 kDa.
Purity: > 95% by SDS-PAGE.
Formulation: Human Thyroglobulin is supplied in 16 mM HEPES buffer pH-7.6, 240 mM sodium chloride, and 20% glycerol.
Applications: ELISA.

Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.

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TG Protein

Thyroglobulin, TGN, AITD3

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