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Conditions of optimal TECK Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
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Introduction
CCL25 (Teck) is a novel CC chemokine, which is distantly related (about 20% amino acid sequence identity) to other CC chemokines. The mouse CCL25 cDNA has also been cloned and shown to encode a 144 a.a. protein, which exhibits 49% a.a. sequence identity to the human CCL25. Human and mouse CCL25 expression was shown to be greatly restricted to the thymus and small intestine. While dendritic cells are identified as the source of CCL25 production in the thymus, dendritic cells derived from bone marrow do not express CCL25. CCL25 signals through the CCR9 receptor. Teck is possibly involved in T-cell development.
Recombinant human and mouse Teck were shown to be chemotactic for activated macrophages, dendritic cells and thymocytes. The recombinant protein demonstrates chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritic cells but is inactive on peripheral blood lymphocytes and neutrophils.
BP000301-CHM-364: Recombinant Human Thymus Expressed Chemokine (CCL25)
Source: E. coli-derived.
A single, non-glycosylated, polypeptide chain containing 127 amino acids and having a molecular mass of 14.2 kDa.
Determined by its ability to chemoattract human monocytes using a concentration range of 1-10 ug/ml corresponding to a Specific Activity of 10,000-100,000 IU/mg.
Purity > 97%, by SDS-PAGE and RP-HPLC.
Formulation: Filtered (0.2 um) and lyophilized from a concentrated (1 ug/ml) solution in 20 mM PB, pH 7.4, 150 mM NaCl.
Reconstitution: It is recommended to reconstitute the lyophilized TECK in sterile 18 M?-cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.
Other TECK Protein:
Recombinant Mouse Thymus Expressed Chemokine (CCL25)
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