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Conditions of optimal TARC Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Introduction
TARC cDNA encodes a 94 amino acid precursor protein with a 23 amino acid residue signal peptide that is cleaved off to generate the 71 amino acid residue mature secreted protein. TARC is expressed in thymus, and at a lower level in the lung, colon, and small intestine. TARC is in addition transiently expressed in stimulated peripheral blood mononuclear cells. Recombinant TARC has been shown to be chemotactic for T cell lines but not monocytes or neutrophils. CCL-17 was recently identified to be a specific functional ligand for CCR4, a receptor that is selectively expressed on T cells. CCL17 is one of quite a few Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. CCL17 shows chemotactic activity for T lymphocytes, but not monocytes or granulocytes. CCL17 binds to chemokine receptors CCR4 and CCR8. This chemokine plays important roles in T cell development in thymus as well as in trafficking and activation of mature T cells.
BP000306-CHM-240: Recombinant Human TARC (CCL17)
Source: E. coli-derived.
A single,non-glycosylated, polypeptide chain containing 71 amino acids and having a molecular mass of 8 kDa.
Determined by its ability to chemoattract human T-Lymphocytes using a concentration range of 1.0-10.0 ug/ml corresponding to a Specific Activity of 10,000-100,000 IU/mg.
Purity > 97%, by SDS-PAGE and RP-HPLC.
Formulation: Lyophilized from a concentrated (0.5 ug/ml) solution containing 20 mM PBS & 150 mM NaCl pH-7.4.
Reconstitution: It is recommended to reconstitute the lyophilized CCL17 in sterile 18 M?-cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.
Other TARC Proteins:
Recombinant Human TARC (CCL17), His Tag
Recombinant Mouse TARC (CCL17)
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