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Home > Antibodies > A-Z Primary Antibodies > CD35 Antibody

CD35 Antibody

CR1 Antibody

Catalog No. Product Name Size List Price (US$) Quantity
PA000302-000101C05 CR1 (CD35) Monoclonal Antibody 100 ug 275.00
PA000302-000101C05 CR1 (CD35) Monoclonal Antibody 200 ug 400.00
PA000302-000101C05 CR1 (CD35) Monoclonal Antibody 1 mg 1000.00
Description

Introduction
Erythrocyte complement receptor 1 (CR1, also known as CD35, C3b/C4b receptor and immune adherence receptor) is a human gene. This protein encoded by this gene is a member of the regulators of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized.

PA000302-000101C05: CR1 (CD35) Monoclonal Antibody

Mouse Monoclonal Antibody.
Specificity/Sensitivity: Anti-human CR1 (CD35).
Applications: 1 ug/100 ul as primary antibody.
Reactivity: Human.
Immunogen: Soluble human CR1.
Purification: IgG is purified from mouse ascites through a Protein A column.
Form of Antibody: 1 mg/ml in PBS containing 0.1% sodium azide as a preservative.
Clone No: KT23.
Isotype: Mouse IgG1.

Storage/Stability: Stable for 1 year at -20°C and 3 months at 4°C. For maximum recovery of the product, centrifuge the original vial after thawing and before removing the cap. Aliquot to avoid repeated freezing and thawing.

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