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Catalog No. | Product Name | Size | List Price (US$) | Quantity |
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Conditions of optimal sRANKL Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
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Introduction
RANKL binds to tnfrsf11b/opg and to tnfrsf11a/rank. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive t-cell proliferation. May be an important regulator of interactions between t-cells and dendritic cells and may play a role in the regulation of the t-cell-dependent immune response. sRANKL may also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy.
BP000173-CYT-334: Recombinant Human RANK Ligand Soluble
Source: E. coli-derived.
A single, non-glycosylated polypeptide chain containing 176 amino acids and having a molecular mass of 20006 Dalton.
The activity as determined by its ability to induce a dose dependant stimulation of IL-8 production in human PBMCs, is 39-51 ug/ml.
Purity > 98%, by SDS-PAGE and RP-HPLC.
Formulation: The protein was lyophilized from a concentrated (1 ug/ml) solution containing 10 mM Na2PO4, pH-8.0.
Reconstitution: It is recommended to reconstitute the lyophilized sRANKL in sterile 18 M?-cm H2O at a concentration of 100 ug/ml, which can then be further diluted to other aqueous solutions.
Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.
Other sRANKL Proteins:
Recombinant Mouse RANK Ligand Soluble
Recombinant Human Soluble RANK Ligand, GST tag
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