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Conditions of optimal SQSTM1 Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
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Introduction
SQSTM1 is an adapter protein which binds ubiquitin and mediates the activation of NFKB1 by TNF-a, NGF and IL-1. SQSTM1 is involved in titin/TTN downstream signaling in muscle cells. SQSTM1 controls signaling cascades through ubiquitination. SQSTM1 participates in cell differentiation, apoptosis, immune response and regulation of K(+) channels. Mutations in UBA domain of the SQSTM1 protein cause Paget disease because the UBA is essential for aggregate sequestration and cell survival.
BP002247-PRO-806: Recombinant Human Sequestosome 1 (SQSTM1) Protein
Source: E. coli-derived.
Recombinant Human Sequestosome 1 (SQSTM1) Protein is a single, non-glycosylated, polypeptide chain containing 264 amino acids (1-356 a.a.) and having a molecular mass of 39.7 kDa. Recombinant Human Sequestosome 1 (SQSTM1) Protein is fused to an 8 amino acid His-Tag at C-terminus and purified by standard chromatography.
Purity: > 90% as determined by SDS-PAGE.
Formulation: SQSTM1 Human solution containing 20 mM Tris-HCl pH8.0, 1 mM DTT and 10% glycerol.
Shipping: The product is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
SQSTM1 Antibody:
SQSTM1 Polyclonal Antibody
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