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Conditions of optimal SOX2 Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
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Introduction
SOX9 is involved in skeletal development. SOX9 regulates the expression of other genes which play a role in chondrogenesis by performing as a transcription factor for these genes. SOX9 takes part in chondrocyte differentiation and, together with steroidogenic factor 1; SOX9 regulates transcription of the anti-Muellerian hormone gene.
Deficiencies of SOX9 result in skeletal malformation syndrome campomelic dysplasia, often with sex reversal. SOX9 is a transcription factor having vast mobility group DNA-binding domain that is expressed in all prechondrocytic and chondrocytic cells throughout embryonic growth. SOX9 Phosphorylation by PKA raises its DNA binding and transcriptional activity. SOX9 controls expression of chondrocyte phenotype related genes. IL-1 and TNF-a decrease SOX9 levels of mRNA and/or protein in chondrocytes, therefore strongly inhibit the expression of genes for cartilage extracellular matrix proteins. SOX9 down-regulation takes part in inhibiting expression of the cartilage phenotype in inflammatory joint diseases.
BP002058-PRO-739: Recombinant Human Sex determining region Y box 9 (SOX9) protein
Source: E.coli-derived.
Recombinant Human Sex determining region Y box 9 (SOX9) protein is single, a non-glycosylated, Polypeptide chain containing 150 amino acids (1-150 a.a.) fused to a GST tag and having a total molecular mass of 43 kDa. Recombinant Human Sex determining region Y box 9 (SOX9) protein is purified by proprietary chromatographic techniques.
Formulation: SOX9 is supplied in 50 mM Tris-Acetate, pH 7.5, 1mM EDTA and 20% Glycerol.
Shipping: The product is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
SOX9 Antibody:
SOX9 (Ab-181) Polyclonal Antibody
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