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Conditions of optimal SMAD4 Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Introduction
SMAD4 is part of the SMAD family of proteins that mediate signal transduction by the TGF-beta/activin/BMP-2/4 cytokine superfamily from receptor Ser/Thr protein kinases at the cell surface to the nucleus. SMAD4 promotes the binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides the function of activation required for SMAD1 or SMAD2 to stimulate transcription acts as a tumor suppressor. SMAD4 is a target molecule for functional inactivation in cervical cancer. SMAD4 is an important biomarker for malignant transformation atakes part in inducing apoptosis by modulating Bcl-2/Bax balance.
BP002073-CF52: Recombinant Human Mothers Against Decapentaplegic Homolog 4 (SMAD4) protein
Source: E. coli-derived.
Recombinant Human Mothers Against Decapentaplegic Homolog 4 (SMAD4) protein is expressed with sequence (Met1-Asp552) of Human SMAD4 fused with a 6 His tag at the C-terminus.
Purity: > 95.0% by SEC-HPLC and reducing SDS-PAGE.
Endotoxin: < 0.1 ng/ug (1 IEU/ug).
Formulation: 0.2 um filtered solution of 20 mM Tris, pH 8.0.
Shipping: The product is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
Other SMAD4 Proteins:
Recombinant Human SMAD4 protein
SMAD4 Antibodies:
Smad4 Polyclonal Antibody
Smad4 Polyclonal Antibody
Smad4 Polyclonal Antibody
Smad4 DPC4 Monoclonal Antibody
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