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Conditions of optimal SMAD2 Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Introduction
SMAD2 is part of the SMAD family of proteins that mediate signal transduction by the TGF-beta/activin/BMP-2/4 cytokine superfamily from receptor Ser/Thr protein kinases at the cell surface to the nucleus. Phosphorylated SMAD2 is then able to form a complex with SMAD4 or SARA. These complexes accumulate in the cell nucleus, where they are directly participating in the regulation of gene expression. SMAD2 mediates the signal of the TGF-beta, and therefore regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. SMAD2 is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein.
TGF-beta 1 acts on adjacent stromal cells to turn on SMAD2 signalling that could lead to stromal decidualization. SMAD2 is the downstream signal transducers of TGF-beta-1 in human dental pulp cells.
BP002071-PRO-691: Recombinant Human SMAD Family Member 2 (SMAD2) protein
Source: E. Coli-derived.
Recombinant Human SMAD Family Member 2 (SMAD2) protein is a single, non-glycosylated polypeptide chain containing 487 amino acids (1-467) and having a molecular mass of 54.4 kDa. Recombinant Human SMAD Family Member 2 (SMAD2) protein is fused to 20 amino acid His-Tag at N-Terminus and purified by standard chromatography techniques.
Purity: > 95.0% as determined by SDS-PAGE.
Formulation: The SMAD2 protein solution contains 20 mM Tris-HCl pH 8, and 100 mM NaCl.
Shipping: The product is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
SMAD2 Antibodies:
Smad2 Polyclonal Antibody
Smad2 Polyclonal Antibody
Smad2 (Ab-467) Polyclonal Antibody
Smad2 (Ab-255) Polyclonal Antibody
Smad2 (Ab-250) Polyclonal Antibody
Smad2 (Ab-245) Polyclonal Antibody
Smad2 (Ab-220) Polyclonal Antibody
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