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Conditions of optimal SLC4A4 Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
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Introduction
SLC4A4 takes part in the regulation of bicarbonate secretion and absorption and intracellular pH. Mutations in SLC4A4 gene are associated with proximal renal tubular acidosis. SLC4A4 is involved in the regulation of intracellular pH in several cell types. SLC4A4 Isoform 2 is particularly expressed in kidney at the level of proximal tubules.
Amino acid subsitution in SLC4A4 results in an increase of chloride transport.
NBC1 takes part in proximal renal tubular acidosis and ocular abnormalities.
BP002273-PRO-688: Recombinant Human Solute Carrier Family 4, Sodium Bicarbonate Cotransporter, Member 4 (SLC4A4) Protein
Source: E. coli-derived.
Recombinant Human Solute Carrier Family 4, Sodium Bicarbonate Cotransporter, Member 4 (SLC4A4) Protein is a single, non-glycosylated polypeptide chain containing 460 amino acids (1-424 a.a.) and having a molecular mass of 51.5 kDa. Recombinant Human Solute Carrier Family 4, Sodium Bicarbonate Cotransporter, Member 4 (SLC4A4) Protein is fused to 37 amino acid His Tag at N-terminus and purified by proprietary chromatographic techniques.
Purity: > 90.0% as determined by SDS-PAGE.
Formulation: The SLC4A4 protein solution contains 20 mM Tris-HCl, pH 7.5, 0.5 mM DTT, 0.1 mM PMSF and 10% glycerol.
Shipping: The product is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
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