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Conditions of optimal SKP2 Enzyme performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Introduction
SKP2 enzyme is a substrate recognition component of the SCF E3 ubiquitin ligase complex which is involved in the ubiquitination and subsequent proteasomal degradation of target proteins which take part in cell cycle progression, signal transduction and transcription. SKP2 specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SKP2 gene is recognized as a protooncogene regularly involved in the pathogenesis of lymphomas. SKP2 is part of the F-box protein family which is known for its 40 amino acid motif, the F-box. F-box proteins comprise 1 of the 4 subunits of ubiquitin protein ligase complex called SCFs, which play a role in phosphorylation-dependent ubiquitination. There are 3 F-box classes: Fbws having WD-40 domains, Fbls having leucine-rich replicates, and Fbxs having either diverse protein-protein interaction or no recognizable motifs. SKP2 is part of the Fbls class.
BP000727-ENZ-376: Recombinant Human SKP2
Source: E. coli-derived.
Predicted molecular mass: 49 kDa.
Formulation: SKP2 is supplied in 50 mM Tris-Acetate, pH-7.5, 1 mM EDTA and 20% Glycerol.
Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.
SKP2 Antibodies:
SKP2 Polyclonal Antibody
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