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| Catalog No. | Product Name | Size | List Price (US$) | Quantity |
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Conditions of optimal SIT1 Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
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Introduction
Signaling Threshold-Regulating Transmembrane Adapter 1 (SIT1) is a single-pass type I membrane protein and specifically expressed in T- and B-cells. SIT1 interacts with PTPN11/SHP2, GRB2 and CSK, when it is phosphorylated. SIT1 negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cell. In addition, SIT1 is involved in positive selection of T-cells.
BP001755-PRO-928: Recombinant Human Signaling Threshold-Regulating Transmembrane Adapter 1 (SIT1) Protein
Source: E. coli-?derived.
Recombinant Human Signaling Threshold-Regulating Transmembrane Adapter 1 (SIT1) Protein is a single, non-glycosylated polypeptide chain containing 156 amino acids (62-196 a.a.) and having a molecular mass of 16.9 kDa (Molecular weight on SDS-PAGE will appear higher). SIT1 is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Purity: > 90.0% by SDS-PAGE.
Formulation: SIT1 protein solution (0.25 mg/ml) containing 20 mM Tris-HCl buffer (pH 8.0) and 20% glycerol.
Shipping: The product is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.
Other SIT1 Protein:
Recombinant Human SIT1 Protein
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