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Conditions of optimal SERPINI1 Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Introduction
SERPINI1 (Neuroserpin) is an inhibitory serpin which is expressed primarily in the central nervous system. Even though the physiological target of SERPINI1 is still vague, amassed evidence suggest that SERPINI1 has an imperative role in controlling proteolytic degradation of extracellular matrix (ECM) during synaptogenesis and the subsequent development of neuronal plasticity. The neuroprotective role of SERPINI1 has been demonstrated in transgenic mice lacking SERPINI1 expression. The deficiency of SERPINI1 in these mice is linked with motor neuron disease characterized by axonal degradation. In humans, defects in SERPINI1, caused by point mutations in the neuroserpin gene, trigger a hereditary disorder known as the familial encephalopathy with neuroserpin inclusion bodies (FENIB).
BP002079-PRO-213: Recombinant Human Neuroserpin (SERPINI1) protein
Source: E. coli-derived.
Recombinant Human Neuroserpin (SERPINI1) protein is a single, non-glycosylated polypeptide chain containing 395 amino acids and having a total molecular mass of 44.6 kDa. Recombinant Human Neuroserpin (SERPINI1) protein is purified by proprietary chromatographic techniques.
Purity: > 97.0% as determined by (a) Analysis by HPLC; (b) Analysis by SDS-PAGE.
Formulation: The protein was Lyophilized from a 0.2 um filtered concentrated solution in 1x PBS, pH 7.4.
Reconstitution: It is recommended to reconstitute the lyophilized SERPINI1 in sterile 18 M-cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-?thaw cycles.
12 months from date of receipt,-20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.
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