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Conditions of optimal Serpin G1 Enzyme performance should be determined experimentally by the investigator.
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Fax: 1-617-606-5019
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Or leave a message with a formal purchase
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Introduction
The human serpin superfamily consists of at least 35 members that target not only serine proteases, but also selected cysteine proteases and non-protease proteins. As protease inhibitors, serpins have an array of functions including regulating blood clotting, the complement pathway, extracellular matrix remodeling, and cell motility. They are also involved in activities that extend beyond their ability to inhibit proteases. For instance, they may also regulate blood pressure, angiogenesis.Plasma protease C1 inhibitor(Serpin G1), also known as SERPIN G1, C1-inhibiting factor, C1-INH, C1 esterase inhibitor, SERPIN G1 and C1IN, is a serine protease inhibitor protein. C1-INH is the largest member among the serpin class of proteins. Remarkably, C1-INH has a 2-domain structure, unlike most family members. The C-terminal serpin domain is similar to other serpins, and this part of C1-INH provides the inhibitory activity. The N-terminal domain is not essential for C1-INH to inhibit proteinases and has no similarity to other proteins. The main function of C1-INH is the inhibition of the complement system to prevent spontaneous activation. C1-INH is an acute phase protein and circulates in blood at levels of around 0.25 g/L, whose levels rise 2-fold during inflammation. Although named after its complement inhibitory activity, C1-INH also inhibits proteinases of the fibrinolytic, clotting, and kinin pathways. Most notably, C1-INH play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins. It is also the most important physiological inhibitor of fXIIa, chymotrypsin and plasma kallikrein.
BP001105-C539: Recombinant Human Serpin G1 Enzyme
Source: HEK 293-derived.
Recombinant Human Serpin G1 Enzyme is a secreted protein with sequence (Asn23-Ala500) of human SERPING1 fused with a polyhistidine tag at the C-terminus.
Purity: > 95% by SEC-HPLC and reducing SDS-PAGE.
Endotoxin: < 0.1 ng/ug (1 EU/ug).
Formulation: Lyophilized from a 0.2 um filtered solution of 20 mM Tris-HCl, 150 mM NaCl, pH 8.0.
Reconstitution: Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in 1X PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.
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