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Conditions of optimal RXRA Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
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Introduction
The retinoid X receptor (RXR) is a pleiotropic nuclear receptor transcription factor that interacts with a variety of nuclear receptor dimeric partner. RXR binds cognate response elements as a homodimer in the presence of its ligand, 9-cis retinoic acid, or as a heterodimer with other members of the nuclear hormone receptor superfamily including retinoic acid receptors (RAR), thyroid hormone receptors (TR), vitamin D receptors and peroxisome proliferators-activated receptors (PPAR). The RXR family includes three different isoforms; RXR a, b, g . Human RXR a gene is localized on 9q34.9 and encodes two major isoforms (RXR a1, RXR a2). The DNA binding domain of RXR (111-228aa) was purified by using conventional column chromatography techniques.
BP002261-PRO-437: Recombinant Human Retinoid X Receptor Alpha (RXRA) Protein
Source: E. coli-derived.
Recombinant Human Retinoid X Receptor Alpha (RXRA) Protein is a single, non-glycosylated polypeptide chain containing 119 amino acids (111-228) and having a molecular mass of 13.6 kDa.
Purity: > 95.0% as determined by SDS-PAGE.
Formulation: The protein containing 20 mM Tris-HCl pH 7.5, 0.1 M NaCl, 5 mM b-Mercaptoethanol.
Shipping: The product is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
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