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Conditions of optimal RRAS2 Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Introduction
RRAS2 (RAS viral (r-ras) oncogene homolog 2) is a member of the Ras like GTPase family that cycle between GTP-bound active and GDP-bound inactive states at the cytoplasmic face of the plasma membrane. RRAS2 is a plasma membrane-associated GTP-binding protein with GTPase activity. RRAS2 is implicated in the pathogenesis of human cancers. Hence, overexpression of active RRAS2 in EpH4 cells induces tumorigenicity through the phosphoinositide 3-kinase, p38 MAPK, and mTOR pathways, as these cells lose their sensitivity to the normal growth inhibitory role of TGF-beta. RRAS2 might transduce growth inhibitory signals across the cell membrane, exerting its effect via an effector shared with the Ras proteins but in an antagonistic manner. RRAS2 is ubiquitously present in all tissues examined, with the highest levels in the heart, placenta, and skeletal muscle. Moderate levels of RRAS2 are found in the lung and liver and low levels in the brain, kidney, and pancreas. RRAS2 deficiencies are linked to ovarian cancer.
BP002265-PRO-728: Recombinant Human Related RAS Viral (r-ras) Oncogene Homolog 2 (RRAS2) Protein
Source: E. coli-derived.
Recombinant Human Related RAS Viral (r-ras) Oncogene Homolog 2 (RRAS2) Protein is a single, non-glycosylated, polypeptide chain containing 221 amino acids (1-201 a.a.) and having a molecular mass of 25.2 kDa. Recombinant Human Related RAS Viral (r-ras) Oncogene Homolog 2 (RRAS2) Protein is purified by proprietary chromatographic techniques.
Purity: > 95.0% as determined by SDS-PAGE.
Formulation: The RRAS2 solution contains 20 mM Tris-HCl buffer (pH 8.0), 1 mM DTT, 10% glycerol and 2 mM EDTA.
Shipping: The product is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
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