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Conditions of optimal RORC Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
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Introduction
RORC is a DNA-binding transcription factor which belongs to the NR1 subfamily of nuclear hormone receptors. The specific functions of the RORC protein are not known; nevertheless, studies of a similar gene in mice have shown that the RORC gene may be vital for lymphoid organogenesis and may have an imperative regulatory role in thymopoiesis. Furthermore, studies in mice suggest that RORC may inhibit the expression of Fas ligand and IL2. RORC may be a possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. RORC is Crucial for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. RORC is also involved in lineage specification of uncommitted CD4 (+) T helper cells into Th17 cells. In addition, RORCs regulate the expression of several components of the circadian clock.
BP002290-PRO-206: Recombinant Human RAR-Related Orphan Receptor C (RORC) Protein
Source: E. coli-derived.
Recombinant Human RAR-Related Orphan Receptor C (RORC) Protein is a full length protein consisting of 497 amino acids having a molecular weight of 55.8 kDa and fused with 5.5 kDa amino-terminal His-Flag tag. Recombinant Human RAR-Related Orphan Receptor C (RORC) Protein is purified by proprietary chromatographic techniques.
Purity: > 80.0% as determined by SDS-PAGE.
Formulation: RORC protein is supplied in 50 mM Tris, 150 mM NaCl and 10% Glycerol, pH 7.5.
Shipping: The product is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
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