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Conditions of optimal ROBLD3 Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
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Introduction
ROBLD3 is a member of the GAMAD family. ROBLD3 is an adapter protein which enhances the efficiency of the MAP kinase cascade and facilitates the activation of MAPK2. ROBLD3 compels the recruitment of MP1 to late endosomes where they form a very stable heterodimeric complex required for ERK activation on endosomes. In humans, a mutation in the ROBLD3 gene has been associated with a primary immunodeficiency syndrome, and suggests a role for the ROBLD3 protein in endosomal biogenesis.
BP002291-PRO-050: Recombinant Human Roadblock Domain Containing 3 (ROBLD3) Protein
Source: E. coli-derived.
Recombinant Human Roadblock Domain Containing 3 (ROBLD3) Protein fused with a 24 amino acid His tag at N-terminus is a single, non-glycosylated, polypeptide chain containing 149 amino acids (1-125 a.a.) and having a molecular mass of 16 kDa. Recombinant Human Roadblock Domain Containing 3 (ROBLD3) Protein is purified by proprietary chromatographic techniques.
Purity: > 95.0% as determined by SDS-PAGE.
Formulation: The ROBLD3 solution (1 mg/ml) contains 20 mM Tris-HCl buffer (pH 8.0), 0.2 M Nacl, 2 mM DTT and 10% glycerol.
Shipping: The product is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
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