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Conditions of optimal RND3 Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Introduction
RND3 is a small GTPase which is part of the Ras superfamily that controls the association of the actin cytoskeleton in reaction to extracellular growth factors. RND3 activity causes a decrease in stress fibers and an increase in cell migration, at least in part through regulation of the Rho-dependent kinase ROCK1. RND3 inhibits DNA-damage induced apoptosis and cell cycle arrest. RND3 binds GTP and is resistant to Rho-specific GTPase-activating proteins.
BP002293-PRO-487: Recombinant Human Rho Family GTPase 3 (RND3) Protein
Source: E. coli-derived.
Recombinant Human Rho Family GTPase 3 (RND3) Protein is a single, non-glycosylated polypeptide chain containing 261 amino acids (1-241 a.a.) and having a molecular mass of 29.2 kDa. The RND3 is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
Purity: > 90.0% as determined by SDS-PAGE.
Formulation: RND3 Human solution containing 20 mM Tris-HCl pH-8, 1 mM DTT, 1 mM EDTA, 0.1 M NaCl & 40% glycerol.
Shipping: The product is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
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