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The manufacturing conditions of Rituxan biosimilar from the CHO stable cell line need to be optimized by clients.
The cheapest research grade rituximab biosimilar protein (1 mg for >$30) is also available.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
B-lymphocyte antigen CD20 encoded by the MS4A1 gene is an activated-glycosylated phosphoprotein on the surface of all B-cells. The function of the membrane protein is to stimulate B-cell immune response, specifically against T-independent antigens though its natural ligand remains unknown. CD20 is important for the development and differentiation of B-cells into plasma cells. CD20 belongs to the membrane-spanning 4A family with common structural features, similar intron/exon splice boundaries, and unique expression patterns among hematopoietic cells and nonlymphoid tissues.
Rituximab (trade names Rituxan and MabThera), a chimeric anti-CD20 monoclonal antibody, destroys B cells and is used to treat diseases with excessive numbers of B cells, overactive B cells, or dysfunctional B cells, such as many lymphomas, leukemias, transplant rejection, and autoimmune disorders.
C010: Rituxan Biosimilar Stable Cell Line (CHO)
The yield of Rituxan biosimilar from the CHO stable cell line was above 1.8 g/L in a 3 liter manufacturing.
The stable cell line alone can be transfered alone or together with the technology of process development and/or antibody purification.
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