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| Catalog No. | Product Name | Size | List Price (US$) | Quantity |
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Conditions of optimal RBL2 antibody performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Introduction
RBL2(Retinoblastoma-like protein 2) is a protein that in humans is encoded by the RBL2 gene. It is also known as Retionblastoma-related gene (RB2), P130. Yeung et al. (1993) mapped the RBL2 gene to human chromosome 16q12.2 and rat chromosome 19, using fluorescence in situ hybridization and somatic hybrid cell analysis, respectively. Based on known syntenic relationships among human, rat and mouse, the data suggested that the mouse homolog resides on chromosome 8. Deletions of chromosome 16q have been found in several human neoplasms, including breast, ovarian, hepatic, and prostate cancers, which supports the involvement of RB2 in human cancer as a tumor suppressor gene. Kong et al. (2006)found that RBL2 and RINT1 were essential for telomere length control in human fibroblasts, with loss of either protein leading to longer telomeres. Williams et al. (2006)found that mouse fibroblasts lacking Rb were less susceptible to an oncogenic HRAS allele than wildtype cells.
PA003154-PA1895: RBL2 Polyclonal Antibody
Rabbit Polyclonal Antibody.
Applications: WB: 0.1-0.5 ug/ml.
Reactivity: Human, Rat, Mouse.
Immunogen: A synthetic peptide corresponding to a sequence at the C-terminal of human RBL2, identical to the related rat sequence and different from the related mouse sequence by one amino acid.
Purification: Immunogen affinity purified.
Form of Antibody: Lyophilized.
Isotype: Rabbit IgG.
Storage/Stability: Stable for 1 year at -20°C and 3 months at 4°C. For maximum recovery of the product, centrifuge the original vial after thawing and before removing the cap. Aliquot to avoid repeated freezing and thawing.
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