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| Catalog No. | Product Name | Size | List Price (US$) | Quantity |
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Conditions of optimal RAP Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Introduction
Receptor-associated Protein (aka RAP) averts the GCM-mediated enhancement of axon growth- ApoE-containing lipoproteins which are known to bind to receptors of the LDLr superfamily. In the presence of RAP, GCM doesn increase the axon extension rate in relation to base medium. Furthermore, the addition of RAP to the base medium doesn change the rate of axon extension. This implies that the growth stimulatory effect of apoE-containing lipoproteins secreted by glial cells is mediated by the LDLr family receptors. RAP annuls the growth stimulatory effect of GCM.
BP003003-PRO-352: Recombinant rat Receptor Associated Protein (RAP) Protein
Source: E. coli-derived.
Recombinant rat Receptor Associated Protein (RAP) Protein is a single, non-glycosylated polypeptide chain having a molecular mass of 38,862 Dalton. Recombinant rat Receptor Associated Protein (RAP) Protein contains 6xHis tag and 1xC-myc, RAP Rat is purified by proprietary chromatographic techniques.
Purity: > 95.0% as determined by SDS-PAGE.
Formulation: The protein (1 mg/ml) was lyophilized after from a sterile solution containing TBS pH-7.5, 0.1% BSA and 0.09% NaN3.
Reconstitution: Ligand binding to RAP is Ca2+ dependent and e.g. lipid receptors can be released from RAP by a buffer containing 10 mM EDTA. Furthermore, buffers containing phosphate should be avoided (it would form precipitates with Ca2+).
Shipping: The product is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.
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