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PTH Protein

Parathyroid Hormone, Parathyrin, Parathormone

Catalog No. Product Name Size List Price (US$) Quantity
BP000384-HOR-290 Human PTH Protein (1-34) 1 mg 160.00
BP000384-HOR-290 Human PTH Protein (1-34) 5 mg 450.00
Description

Introduction
Parathyroid hormone (PTH), or parathormone, is secreted by the parathyroid glands as a polypeptide containing 84 amino acids. It acts to increase the concentration of calciumin the blood, whereas calcitonin (a hormone produced by the parafollicular cells of the thyroid gland) acts to decrease calcium concentration. PTH acts to increase the concentration of calcium in the blood by acting upon parathyroid hormone receptorin three parts of the body: In the bones- It enhances the release of calcium from the large reservoir contained in the bones. Bone resorption is the normal destruction of bone by osteoclasts, which are indirectly stimulated by PTH. Stimulation is indirect since osteoclasts do not have a receptor for PTH; rather, PTH binds to osteoblasts, the cells responsible for creating bone. Binding stimulates osteoblasts to increase their expression of RANKL, which can bind to osteoclast precursors containing RANK, a receptor for RANKL. The binding of RANKL to RANK stimulates these precursors to fuse, forming new osteoclasts which ultimately enhances the resorption of bone.
In the kidney- It enhances active reabsorption of calcium from distal tubules and the thick ascending limb.

BP000384-HOR-290: Human Parathyroid Hormone (PTH) Protein (1-34)

Predicted molecular mass: 4117.8 Da.
Purity: > 98% by RP-HPLC.
Formulation: Lyophilized without any additives.
Reconstitution: It is recommended to reconstitute the lyophilized Parathormone in sterile 18 M?-cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.

Shipping: The product is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.

Other PTH Proteins:
Recombinant Human PTH Protein (1-84)
Recombinant Human PTH Protein (1-84)
Recombinant Human PTH Protein (1-34)
Recombinant Human PTH Protein
Recombinant Human PTH Protein (7-34)

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