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Conditions of optimal PSME3 Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
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Introduction
PSME3 is a member of the PA28 family. The 26S proteasome is an extremely organized multicatalytic proteinase complex composed of 2 complexes, a 20S core and a 19S regulator. Proteasomes are spread all over the eukaryotic cells in large quantities and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. PSME3 stimulates the trypsin-like catalytic subunit of the proteasome and inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. PSEM3 enables the MDM2-p53/TP53 collaboration that encourages ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, restricting its growth and causing inhibited apoptosis after DNA damage.
BP002739-PRO-987: Recombinant Human Proteasome Activator Subunit 3 (PSME3) Protein
Source: E. coli-derived.
A single, non-glycosylated polypeptide chain containing 274 amino acids (1-254 a.a.) and having a molecular mass of 31.7 kDa. PSME3 is fused to a 20 amino acid His-tag at N-terminus.
Purity: > 90% as determined by SDS-PAGE.
Formulation: PSME3 protein solution (0.5 mg/ml) containing 20 mM Tris-HCl buffer (pH8.0), 200 mM NaCl, 2 mM DTT and 40% glycerol.
Shipping: The product is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
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