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Conditions of optimal PSMB7 Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
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Introduction
Proteasome subunit beta type-7 (PSMB7) belongs to the proteasome B-type family. PSMB7 is a multicatalytic proteinase complex with an extremely ordered ring-shaped 20S core structure. This core structure is comprised of 4 rings of 28 non-identical subunits; 2 rings are comprised of 7 alpha subunits and 2 rings are comprised of 7 beta subunits. Proteasomes are scattered all over eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent manner in a non-lysosomal pathway. The processing of class I MHC peptides is a vital function of the immunoproteasome (which is a modified proteasome).
BP002737-ENZ-577: Recombinant Human Proteasome Subunit Beta Type 7 (PSMB7) Protein
Source: E. coli-derived.
A single, non-glycosylated polypeptide chain containing 255 amino acids (44-277) and having a molecular mass of 27.6 kDa (Molecular size on SDS-PAGE will appear higher). PSMB7 is fused to a 21 amino acid His-tag at N-terminus.
Purity: > 80.0% as determined by SDS-PAGE.
Formulation: The PSMB7 solution (0.25 mg/ml) contains 20 mM Tris-HCl buffer (pH8.0), 20% glycerol and 1 mM DTT.
Shipping: The product is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
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