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Conditions of optimal PPP1R14A Enzyme performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
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Introduction
Protein Phosphatase 1 Regulatory Subunit 14A (PPP1R14A) belongs to the PP1 inhibitor family. PPP1R14A is mapped to chromosome 19q13.13-q13.2. PPP1R14A binds directly to protein kinase C and casein kinase I. Meantime, PPP1R14A is a phosphorylation-dependent inhibitor of smooth muscle myosin phosphatase. PPP1R14A is the inhibitor of PPP1CA. When phosphorylated, PPP1R14A has over 1000-fold higher inhibitory activity, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction. In addition, inhibition of PPP1R14A also enhances contraction of smooth muscle in the absence of increment of intracellular Ca2+ concentration.
BP000782-ENZ-370: Recombinant Human Protein Phosphatase-1 Regulatory Subunit-14A (PPP1R14A) Enzyme
Source: E. coli-derived.
A single, non-glycosylated polypeptide chain containing 167 amino acids and having a molecular mass of 18 kDa.
Purity: > 95% by RP-HPLC and SDS-PAGE.
Formulation: The PPP1R14A protein solution (1 ug/ml) contains 20 mM Tris-HCl, pH-8, 0.2 um EDTA, 1 mM DTT and 10% glycerol.
Shipping: The product is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
Other PPP1R14A Enzymes:
Recombinant Human PPP1R14A Enzyme
PPP1R14A Antibodies:
PPP1R14A Monoclonal Antibody
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