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Conditions of optimal POMC Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Introduction
Pro-opiomelanocortin preproprotein (POMC) is a polypeptide hormone precursor which experiences extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. POMC regulates the corticosteroid production in the adrenal cortex. Furthermore, POMC is cleaved into ten hormone chains named NPP, g-MSH, ACTH, a-MSH, CLIP, Lipotropin b, Lipotropin g, b-MSH,b endorphin and Met-enkephalin. POMC gene defects are the cause of POMC deficiency, which is characterized by red hair and adrenal insufficiency.
BP002904-PRO-236: Recombinant Human Proopiomelanocortin (POMC) Protein
Source: E. coli-derived.
Recombinant Human Proopiomelanocortin (POMC) Protein is a single, non-glycosylated polypeptide chain containing 262 amino acids (27-267 a.a) and having a molecular mass of 28.9 kDa (molecular weight on SDS-PAGE will appear higher). Recombinant Human Proopiomelanocortin (POMC) Protein is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Purity: >85% as determined by SDS-PAGE.
Formulation: POMC protein solution (0.25 mg/ml) containing 20 mM Tris-HCl buffer (pH 8.0), 1 mM DTT, 50% glycerol and 0.2 M NaCl.
Shipping: The product is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
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