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Background Information:
A selective inhibitor of B-RAF protein kinase carrying V600E mutation with a Ki at 13 nM.
Reference:
1. J. Tsai, et al., Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity. Proc Natl Acad Sci USA. 105(8), 3041-6 (2008).
APIM050229: PLX4720
CAS No.: 918505-84-7.
Molecular Formula: C17H14ClF2N3O3S.
Molecular Weight: 413.8.
Purity: >99% (HPLC at 214 and 254 nm).
QC: LC/MS, 1HNMR.
Solubility: Soluble in DMSO.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.
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