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Conditions of optimal PI3Kg Enzyme performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
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Fax: 1-617-606-5019
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Introduction
PI3Kg is highly expressed in cells of hematopoietic origin. It plays an important role in dendritic cell (DC) trafficking and in the activation of specific immunity. PI3Kg-/- mice showed a reduced ability to respond to chemokines, and had a selective defect in the number of skin Langerhans cells and in lymph node CD8a-DCs. In macrophages, the chemokine RANTES/CCL5 activates the small GTPase Rac1 and its downstream target PAK2. This response depends on Gi activation and largely on the subsequent triggering of PI3Kg.
BP000797-PKA-329: Recombinant Human Phosphoinositide 3-kinase p110g
Source: Sf9 insect cells-derived.
Predicted molecular mass: 126.3 kDa.
4.5 nmol/mg/min using phosphatidylinositol as the substrate.
Purity > 95%, by SDS-PAGE.
Formulation: Protein solution (1 ug/ml) in 25 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.5 mM MgCl2 and 50% glycerol.
Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
Other PI3Kg Enzymes:
Recombinant Human Phosphoinositide 3-kinase p110γ inactive mutant
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