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Background Information:
A potent, selective (>1000-fold more selective than other 208 kinases), orally bioavailable c-Met kinase inhibitor with Ki at low nM.
Reference:
1. S. L. Timofeevski, et al, Enzymatic Characterization of c-Met Receptor Tyrosine Kinase Oncogenic Mutants and Kinetic Studies with Aminopyridine and Triazolopyrazine Inhibitors, Biochemistry, 2009, 48 (23), 5339–5349.
APIM050224: PF-04217903
CAS No.: 1159490-85-3.
Molecular Formula: C19H16N8O.
Molecular Weight: 372.38.
Purity: ≥ 99% (HPLC).
QC: LC/MS, 1HNMR.
Solubility: Soluble in DMSO, water (pH < 7).
Storage: Store at 0°C (short term), -20°C (long term), desiccated.
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