Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Catalog No. | Product Name | Size | List Price (US$) | Quantity |
---|
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Background Information:
PF-02341066 (R-Crizotinib) is a cell-permeable, specific ATP-competitive small-molecule inhibitor of c-Met (Ki =4 nM) and anaplastic lymphoma kinase (ALK) (IC50 = 28 nM).
Reference:
1. Zou, H.Y., et al, An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms, Cancer Res. 67: 4408-4417 (2007).
2. Bang, Y., et al, Clinical activity of the oral ALK inhibitor PF-02341066 in ALK-positive patients with non-small cell lung cancer (NSCLC), J. Clin. Oncol. 28: 3 (2010).
APIM050222: PF-02341066
CAS No.: 877399-52-5.
Molecular Formula: C21H22Cl2FN5O ?0.5H2O.
Molecular Weight: 459.3.
Purity: 100% optical purity (Chiral HPLC), >99% purity (HPLC at 214 and 254 nm).
QC: HPLC-MS, 1HNMR, Chiral HPLC, and Quantitative Elemental Analysis.
Solubility: Soluble in DMSO and water with 2 eq. of acid.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.
Copyright © 2009-2022 sydlabs.com. All rights reserved.
Use of this website means that you have read, understood, and accepted the Syd Labs Privacy Policy and Terms & Conditions.