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Conditions of optimal PEBP1 Protein performance should be determined experimentally by the investigator.
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Fax: 1-617-606-5019
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Or leave a message with a formal purchase
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Introduction
PEBP1 (Phosphatidylethanolamine binding protein 1) belongs to the phosphatidylethanolamine-binding protein family and a serine protease inhibitor that inhibits thrombin, neuropsin. PEBP1 plays a key modulatory part in several protein kinase signaling cascades. PKC phosphorylates PEBP1, resulting in the release of Raf-1 and activation of MEK and ERK. PEBP1 is expressed in many tissues and implicated in the regulation of such physiological processes as membrane biosynthesis, spermatogenesis, neural development, and metastasis suppression.
PEBP1 binds ATP, opioids and phosphatidylethanolamine, however it has lower affinity for phosphatidylinositol and phosphatidylcholine. PEBP1 may also be involved in the function of the presynaptic cholinergic neurons of the CNS. PEBP1 increases the production of choline acetyltransferase although not acetylcholinesterase. Furtheremore, PEBP1 functions in potentially sequestering toxic compounds, including locostatin which may have harmful effects on cells.
Loss of PEBP1 expression may have a significant role as prognostic marker in Gastrointestinal stromal tumors. In addition, PEBP1 is found differentially expressed in the Wernicke's Area from schizophrenia patients. PEBP1 is also, an invasion suppressor protein in nasopharyngeal carcinoma.
BP002912-PRO-722: Recombinant Human Phosphatidylethanolamine-binding protein 1 (PEBP1) Protein
Source: E. coli-derived.
Recombinant Human Phosphatidylethanolamine-binding protein 1 (PEBP1) Protein is a single, non-glycosylated, polypeptide chain containing 187 amino acids (1-187 a.a.) and having a molecular mass of 21 kDa. Recombinant Human Phosphatidylethanolamine-binding protein 1 (PEBP1) Protein is purified by proprietary chromatographic techniques.
Purity: >95.0% as determined by SDS-PAGE.
Formulation: The PEBP1 protein solution contains 20 mM Tris-HCl buffer (pH 8.0), 1 mM DTT and 10% glycerol.
Shipping: The product is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
PEBP1 Antibodies:
PEBP1 Polyclonal Antibody
PEBP1 Polyclonal Antibody
PEBP1 Polyclonal Antibody
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