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| Catalog No. | Product Name | Size | List Price (US$) | Quantity |
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Conditions of optimal PEA15 Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
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Introduction
Astrocyticphosphoprotein PEA-15 (PEA15) is a death effector domain (DED)-containing protein. PEA15 is mainly expressed in the central nervous system, principally in astrocytes. Increased PEA15 levels affect tumorigenesis and cancer progression. PEA15 is overexpressed in breast cancers and gliomas as well as in type 2 diabetes. PEA15 blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. PEA15 also inhibits RPS6KA3 activities by holding it in the cytoplasm. In addition, PEA15 inhibits both TNFRSF6 and TNFRSF1A mediated CASP8 activity and apoptosis. At present, PEA15 expression is also a significant prognostic marker in ovarian cancer.
BP002622-PRO-729: Recombinant Human Astrocytic Phosphoprotein PEA-15 (PEA15) Protein
Source: E. coli-derived.
Recombinant Human Astrocytic Phosphoprotein PEA-15 (PEA15) Protein is a single, non-glycosylated, polypeptide chain containing 130 amino acids (1-130 a.a.) and having a molecular mass of 15 kDa. Recombinant Human Astrocytic Phosphoprotein PEA-15 (PEA15) Protein is purified by proprietary chromatographic techniques.
Purity: > 90.0% as determined by SDS-PAGE.
Formulation: The PEA15 protein solution contains 20 mM Tris-HCl buffer (pH 7.5), 1 mM DTT and 10% Glycerol.
Shipping: The product is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
Other PEA15 Proteins:
Recombinant Human PEA15 Protein
PEA 15 Antibodies:
PEA15 Polyclonal Antibody
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