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| Catalog No. | Product Name | Size | List Price (US$) | Quantity |
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Conditions of optimal PDGF BB Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
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Introduction
PDGF-BB is a member of the platelet-derived.growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived.growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 7, at sites where this gene and that for COL1A1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two splice variants have been identified for this gene.
BP000245-CYT-412: Recombinant Mouse PDGF BB
Source: E. coli-derived.
A homodimeric, non-glycosylated, polypeptide chain containing 2x109 (total of 2 chains 218aa) amino acids and having a total molecular weight of 24.6 kDa.
N-terminal sequence analysis: Met-Ser-Leu-Gly-Ser.
The biological activity is determined by the dose-dependant stimulation of the proliferation of human umbelical vein endothelial cells (HUVEC) using a concentration range of less than 1.6 ug/ml.
Purity > 98%, by SDS-PAGE and RP-HPLC.
Formulation: lyophilized from 10mM NaCitrate pH-3.0.
Reconstitution: It is recommended to reconstitute the lyophilized Platelet-derived.Growth Factor-BB in sterile 100 mM acetic acid and 0.1% BSA not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
1 month, 2 to 8°C under sterile conditions after reconstitution.
3 months, -20 to -70°C under sterile conditions after reconstitution.
Other PDGF BB Proteins:
Recombinant Human PDGF BB
Recombinant Human PDGF BB, Yeast
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