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Conditions of optimal PDCD4 Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
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Introduction
PDCD4 is restricted to the nucleus in proliferating cells. Expression of PDCD4 is modulated by cytokines in natural killer and T cells. PDCD4 takes part in apoptosis. PDCD4 is a translation inhibitor targeted for degradation during tumor promotion. PDCD4 promotes colonic neoplastic transformation and tumor invasion. PDCD4 is an important target for microrna R-21 in breast cancer cells. Shortage of PDCD4 expression is associated with colorectal cancer.
PDCD4 is swiftly phosphorylated by S6K1 kinase protein & afterwords degraded by ubiquitin ligase SCF in response to mitogens.
PDCD4 in response to mitogens allows competent protein synthesis & cell growth. PDCD4 is a proapoptotic protein involved in TGF-beta1-induced apoptosis in human HCC cells, and a tumor suppressor in hepatocarcinogenesis. PDCD4 restraines tumor progression in colon carcinoma cells by the novel mechanism of down-regulating MAP4K1 transcription, with consequent inhibition of c-Jun activation and AP-1-dependent transcription.
Overexpression of PDCD4 in carcinoid cells results in inhibition of cell proliferation.
BP002398-PRO-606: Recombinant Human Programmed Cell Death 4 (PDCD4)
Source: E. coli-derived.
Recombinant Human PDCD4 protein is a single, non-glycosylated polypeptide chain containing 469 amino acids and having a molecular mass of 51 kDa.
Purity: > 90.0% by RP-HPLC and SDS-PAGE.
Formulation: The protein solution contains 20 mM Tris-HCl pH-8, 1 mM DTT and 0.1 M sodium chloride.
Shipping: The product is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
Other PDCD4 Proteins:
Recombinant Human PDCD4 Protein
PDCD4 Antibodies:
PDCD4 (Ab-457) Polyclonal Antibody
PDCD4 (Ab-67) Polyclonal Antibody
PDCD4 (Phospho-Ser67) Polyclonal Antibody
PDCD4 (Phospho-Ser457) Polyclonal Antibody
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