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Conditions of optimal PAIP2 Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
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Introduction
PAIP2 has a role as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. PAIP2 inhibitory activity on translation is mediated through its action on PABPC1. PAIP2 displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. PAIP2 association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization.
BP002918-PRO-748: Recombinant Human Polyadenylate-binding protein-interacting protein 2 (PAIP2) Protein
Source: E. coli-derived.
Recombinant Human Polyadenylate-binding protein-interacting protein 2 (PAIP2) Protein is a single,non-glycosylated polypeptide chain containing 147 amino acids (1-127 a.a.) and having a molecular mass of 17.1 kDa.
Recombinant Human Polyadenylate-binding protein-interacting protein 2 (PAIP2) Protein is fused to 20 amino acid His Tag at N-terminus and purified by convential chromatogrpahy techniques.
Purity: >90.0% as determined by SDS-PAGE.
Formulation: The PAIP2 protein solution contains 20 mM Tris-HCl, pH 8, 1 mM DTT & 10% Glycerol.
Shipping: The product is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
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