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Conditions of optimal p57 Kip2 antibody performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
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Or leave a message with a formal purchase
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Introduction
CDKN1C(Cyclin-dependent kinase inhibitor 1C) also called p57(KIP2) or KIP2, is a protein which in humans is encoded by the CDKN1C imprinted gene. The CDKN1C gene encodes p57(KIP2), a potent tight-binding inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. The CDKN1C gene is paternally imprinted, with preferential expression of the maternal allele. Matsuoka et al. (1995) demonstrated that the CDKN1C gene is located on chromosome 11p15.5, a region implicated in both sporadic cancers and Beckwith-Wiedemann syndrome, a familial cancer syndrome, making it a tumor suppressor candidate. The CDKN1C gene contains 3 exons. Mutations of CDKN1C are implicated in sporadic cancers and Beckwith-Wiedemann syndromesuggesting that it is a tumor suppressor candidate. Diaz-Meyer et al. (2005) concluded that CDKN1C may be downregulated by multiple mechanisms including some that do not involve promoter methylation.
PA002885-PA1876: p57KIP2 Polyclonal Antibody
Rabbit Polyclonal Antibody.
Applications: WB: 0.1-0.5 ug/ml.
Reactivity: Rat, Mouse.
Immunogen: A synthetic peptide corresponding to a sequence at the N-terminal of mouse CDKN1C, identical to the related rat sequence, and different from the related human sequence by two amino acids.
Purification: Immunogen affinity purified.
Form of Antibody: Lyophilized.
Isotype: Rabbit IgG.
Storage/Stability: Stable for 1 year at -20°C and 3 months at 4°C. For maximum recovery of the product, centrifuge the original vial after thawing and before removing the cap. Aliquot to avoid repeated freezing and thawing.
Other p57 Kip2 Antibodies:
p57KIP2 Polyclonal Antibody
p57 Kip2 (Ab-310) Polyclonal Antibody
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