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| Catalog No. | Product Name | Size | List Price (US$) | Quantity |
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Conditions of optimal P2X3 antibody performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
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Background
Purinergic receptor P2X, ligand-gated ion channel, 3, also known as P2X3, is a human gene. Its gene is mapped to 11q12. P2X purinoceptors are 397 to 492 amino acids long and have a predicted structure of 2 short intracellular domains, 2 transmembrane-spanning regions, and a large extracellular domain.The P2X3 subunit has 43% and 47% identity with P2X1 and P2X2, respectively; 10 cysteine residues are conserved in all 3 subtypes, so that tertiary structures may also be conserved.1 P2X3 was the only ligand-gated channel known to be expressed exclusively by a subset of sensory neurons. The remarkable selectivity of expression of the channel, coupled with a sensory neuron-like pharmacology,suggested that it may transduce ATP-evoked nociceptor activation.2 If ATP, and more specifically, P2X3 purinoceptors are involved in nociception, then the development of an antagonist selective for P2X3 could prove useful in pain relief. Lack of P2X3 in other tissues than sensory ganglia could afford a degree of specificity, leading to fewer side effects.3
PA000196-PA1213: P2X3 Polyclonal Antibody
Rabbit Polyclonal Antibody.
Specificity/Sensitivity: Human, mouse, rat. No cross reactivity with other proteins.
Applications: WB 1 ug/ml IHC-P 1-2ug/ml.
Reactivity: Human, Mouse, Rat.
Immunogen: A synthetic peptide corresponding to a sequence at the N-terminal of human P2X3, different from the related rat sequence by three amino acids, and from the related mouse sequence by two amino acids.
Purification: Immunogen affinity purified.
Form of Antibody: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg NaN3.
Storage/Stability: Stable for 1 year at -20°C and 3 months at 4°C. For maximum recovery of the product, centrifuge the original vial after thawing and before removing the cap. Aliquot to avoid repeated freezing and thawing.
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