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Conditions of optimal P-Glycoprotein antibody performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
order (PO) Or credit card.
Background
P-Glycoprotein,, also known as Multidrug Resistance 1 (MDR1), is one of the ATP-binding cassette transporters family. P-glycoprotein-1 is involved in the transport of 3 of these protease inhibitors in vitro.MDR1 gene is mapped to the 7q21.1 by in situ hybridization. The MDR1 gene product, P glycoprotein, mediates the transport of the cardiac glycoside, digoxin.
PA000080-MA1060: P-Glycoprotein Monoclonal Antibody
Mouse Monoclonal Antibody.
Specificity/Sensitivity: Human. No cross reactivity with other proteins.
Applications: Western blot: At 0.5-1 ug/ml with the appropriate system to detect MDR in cells and tissues. Immunohistochemistry(P): At 1-2ug/ml to detect MDR in formalin fixed and paraffin embedded tissues. Boiling the sections is required. Immunohistochemistry(F): At 1-2ug/ml to detect MDR in formalin or acetone fixed tissues.
Reactivity: Human.
Immunogen: A mixture of human and hamster drug-resistant whole cells and crude plasma membranes.
Purification: Purified by the goat anti-mouse IgG affinity chromatography.
Form of Antibody: Lyophilized from 1.2% sodium acetate, with 2 mg BSA and 0.01 mg NaN3 as preservative.
Clone: PG-13.
Isotype: Mouse IgG1.
Storage/Stability: Stable for 1 year at -20°C and 3 months at 4°C. For maximum recovery of the product, centrifuge the original vial after thawing and before removing the cap. Aliquot to avoid repeated freezing and thawing.
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