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Conditions of optimal OPG Fc Protein performance should be determined experimentally by the investigator.
Price/availability/specifications subject to change without notice. Unless otherwise indicated, our catalog and customized products are for research use only and not intended for human or animal diagnostic or therapeutic use.
Phone: 1-617-401-8149
Fax: 1-617-606-5019
Email: message@sydlabs.com
Or leave a message with a formal purchase
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Introduction
Osteoprotegerin acts as decoy receptor for rankl and thereby neutralizes its function in osteoclastogenesis. OPG inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local rankl/opg ratio. Osteoprotegerin may also play a role in preventing arterial calcification. May act as decoy receptor for trail and protect against apoptosis. Trail binding blocks the inhibition of osteoclastogenesis.
BP000227-CYT-633: Recombinant Human Osteoprotegerin, Hi-5
Source: Hi-5-derived.
Recombinant human Osteoprotegerin produced in baculovirus is a single, glycosylated polypeptide chain containing 398 amino acid residues (22-401 a.a.), having a calculated molecular mass of 45.6 kDa. The human Osteoprotegerin is fused to a 6 x His tag at C-terminus and purified by proprietary chromatographic techniques.
Purity: >85% by SDS-PAGE.
Formulation: Osteoprotegerin protein contains PBS pH-7.4 and 10% glycerol.
Shipping: The product is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70°C as supplied.
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