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Background Information:
A potent and selective inhibitor of cysteine protease cathepsin K (IC50 0.2 nM), discriminating against cathepsin B (1034 nM), L (2995 nM), and S (60 nM). The product Odanacatib has been in clinical evaluation as the first-in-class drug treating postmenopausal women with osteoporosis.
Reference:
1. J. Y. Gauthier, et al, Bioorganic & Medicinal Chemistry Letters (2008), 18 (3), 923 – 928.* Perfect HPLC, Chiral HPLC, NMR + Quantitative Elemental Analysis + appearance (snow-white powder) , no impurities (not a bit) visible by any analytical methods - a true testament to the superior quality.
APIM050362: ODANACATIB
CAS No.: 603139-19-1.
Molecular Formula: C25H27F4N3O3S ? 0.1H2O.
Molecular Weight: 527.4.
Purity: >99.8% chem and optical purity (HPLC and chiral HPLC at 214 and 254 nm).
QC: HPLC-MS, 1HNMR, Chiral HPLC, and Quantitative Elemental Analysis.
Solubility: Soluble in DMSO, Alcohols, Common Organic Solvents.
Storage: Store at 0°C (short term), -20°C (long term), desiccated.
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